Experimental study demonstrates copper-catalyzed synthesis of 1,2-dihydro-1,3,5-triazines using amidines and dimethylethanolamine, highlighting a novel oxidative annulation pathway.
1,2-Dihydro-1,3,5-triazines and symmetrical 1,3,5-triazines were obtained in up to 81% yields from amidines and N,N-dimethylethanolamine catalyzed by CuCl2. The reaction involves three C-N bond formations during the oxidative annulation process and the mechanism was proposed. This efficient synthesis of 1,2-dihydro-1,3,5-triazines was developed for the first time.
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Yan et al. (2020) studied this question.
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