Key result
This commentary reviews the mechanistic perspectives of exercise-induced improvements in gut microbial characteristics and their link to vascular health outcomes.
Why the study?
Motivated by the clinical significance of exercise and the gut microbiome, the objective was to assist in defining the gut-vascular axis while identifying biomarkers of gut microbial health linked to vascular function.
This commentary highlights the potential mechanisms by which exercise improves vascular health through modulation of the gut microbiome.
Microbiome-exercise links in vascular health remain mechanistically unclear; leaves open targeted interventions pending direct evidence.
Given the participation of the microbiome in human health and disease, understanding the context of host-microbe interactions involved in vascular pathophysiology is now evolving through identifying microbial communities, specific taxa, and metabolic profiling which can be coupled to human health outcomes. Exercise has been used to define mechanisms related to improved vascular health, which may involve the microbiome. Motivated by the clinical significance that both exercise and the gut microbiome have; the objective of our work is to assist in defining the gut-vascular axis while identifying biomarkers of gut microbial health linked to vascular function. In this commentary, we will provide context to the mechanistic perspectives of exercise-induced improvements in gut microbial characteristics coupled to vascular health outcomes and offer insight on necessary future prospective investigations.
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Cook et al. (2021) conducted a review in Vascular pathophysiology. Exercise was evaluated. This commentary reviews the mechanistic perspectives of exercise-induced improvements in gut microbial characteristics and their link to vascular health outcomes.
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