Key result
Sixty percent of women and 35% of men in a Canadian First Nation community were at increased cardiovascular risk due to low apolipoprotein A1 levels.
Cross-Sectional (n=483)
No
Apolipoprotein and lipid profiles indicate a high cardiovascular risk burden in this Canadian First Nation population, particularly driven by low apoA1 levels and obesity.
Low apoA1 levels were associated with high CV risk in this First Nation community, especially women; leaves open whether apoA1 screening improves risk stratification.
INTRODUCTION: Despite high diabetes rates among Canadian First Nations people, little is known about their cardiovascular disease risk. Our aim was to describe the apolipoprotein profile with respect to cardiovascular risk in a Canadian First Nation community. METHODS: In 2003, a representative sample of adult members of a Manitoba First Nation (N = 483) participated in a screening study for diabetes and diabetes complications. We assessed their cardiovascular risk factors. RESULTS: Sixty percent of women were at increased cardiovascular risk because of low apolipoprotein A1 (apoA1) levels, compared with 35% of men. The proportion of women with low apoA1 levels decreased with age, but the proportion with low high-density lipoprotein levels remained stable across age groups. Both apoB and apoA1 were significantly associated with obesity when age, sex, diastolic blood pressure, homocysteine, diabetes, and insulin resistance were controlled for. CONCLUSION: Apolipoprotein and lipid profiles in this First Nation population suggest high cardiovascular risk. Future research should characterize the lipoprotein particle size in this population.
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Riediger et al. (2010) conducted a cross-sectional in Cardiovascular risk (n=483). Low apolipoprotein A1 (apoA1) levels vs. Normal apolipoprotein A1 levels was evaluated on Increased cardiovascular risk due to low apoA1 levels (women vs men) (p=<0.001). Sixty percent of women and 35% of men in a Canadian First Nation community were at increased cardiovascular risk due to low apolipoprotein A1 levels.
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