Key result
Maximum exercise in COPD patients results in a flat shortening of the QT interval, irrespective of medication taken, which has no impact on mortality.
Why the study?
Does maximum exercise induce changes in QT interval and impact mortality in COPD patients?
Observational
Does maximum exercise induce changes in QT interval and impact mortality in COPD patients?
Exercise-induced QT interval shortening is blunted in COPD patients but does not appear to affect mortality.
Autonomic changes in COPD may signal elevated CV risk; leaves open whether modulation improves outcomes in prospective trials.
Chronic obstructive pulmonary disease (COPD) is a systemic disorder with significant pulmonary and extrapulmonary manifestations [1]. The right and left heart and the great vessels may be affected [2]. Specifically, patients with COPD (especially those with hypoxaemia) have functional alterations in cardiac autonomic modulation, manifested by tachycardia at rest, reduced baroreflex sensitivity, reduced heart rate variability and abnormal recovery of heart rate following exercise [3]. COPD patients establish a flat shortening of QT interval during maximum exercise, irrespectively of medication taken <http://ow.ly/XMrb308wUZt>
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Boutou et al. (2017) conducted an observational in Chronic obstructive pulmonary disease (COPD). Maximum exercise was evaluated on QT interval shortening and mortality. Maximum exercise in COPD patients results in a flat shortening of the QT interval, irrespective of medication taken, which has no impact on mortality.
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