Why the study?
Does blockade of T-type calcium channels prevent proliferation of human pulmonary artery smooth muscle cells?
Population
Early passage human pulmonary artery smooth muscle cells in vitro and human pulmonary arteries in vivo
Design
Preclinical
Authors
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T-type Ca channel blockade may limit pulmonary artery smooth muscle proliferation; leaves open in vivo efficacy in pulmonary hypertension.
Does blockade of T-type calcium channels prevent proliferation of human pulmonary artery smooth muscle cells?
T-type voltage-operated Ca2+ channels, specifically Ca(v)3.1, are essential for the proliferation and cell cycle progression of human pulmonary artery smooth muscle cells.
Rodman et al. (2005) studied this question.
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