Key result
Higher baseline abdominal anthropometric measurements, particularly waist circumference (OR 11.45, p<0.001), were strongly correlated with liver attenuation and independently predicted NAFLD risk.
Why the study?
NAFLD is strongly linked to obesity, particularly abdominal obesity, but underlying causes or risk factors remain incompletely understood.
Do abdominal anthropometric measurements correlate with liver steatosis assessed by unenhanced CT in patients undergoing abdominal imaging?
Cross-Sectional (n=119)
Do abdominal anthropometric measurements correlate with liver steatosis assessed by unenhanced CT in patients undergoing abdominal imaging?
Odds Ratio: 11.45
p-value: p=<0.001
Higher baseline values of abdominal anthropometric measurements on CT strongly correlate with liver attenuation and independently predict NAFLD risk.
Abdominal anthropometrics may link to steatosis severity; leaves open whether they add value beyond routine metabolic assessment.
Background: With a growing frequency, nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. NAFLD has a strong correlation with other metabolic disorders, such as obesity, particularly abdominal obesity, even though the underlying causes or risk factors are not entirely understood. This study aims to investigate correlations between abdominal anthropometric measurements and the presence and intensity of liver steatosis as assessed by unenhanced computed tomography (CT). Methods: One hundred and nineteen patients (male/female, 66/53; mean age 54.54 +/− 12.90 years) underwent abdominal non–contrast-enhanced CT. CT images were examined to determine the attenuation of liver parenchyma, subcutaneous fat depth, and waist circumference (WC). Results: Among all patients, WC (r = −0.78, p < 0.0001), infraumbilical subcutaneous fat thicknesses (r = −0.51, p < 0.0001), right paraumbilical subcutaneous fat thicknesses (r = −0.62, p < 0.0001), and left paraumbilical subcutaneous fat thicknesses (r = −0.53, p < 0.0001) had a high inverse correlation with the liver attenuation values. The presence of T2D (OR: 2.40, p = 0.04), WC (OR: 11.45, p < 0.001), right paraumbilical (OR: 10.09, p < 0.001), left paraumbilical (OR: 2.81, p = 0.01), and infraumbilical (OR: 3.06, p = 0.007) were strongly independent predictors of NAFLD risk. Moreover, regarding the laboratory parameters, only the higher value of GGT (OR: 2.84, p = 0.009) is a predictor of NAFLD risk. Conclusions: Our data show that higher baseline values of all abdominal anthropometric measurements are correlated with liver attenuation and act as predictors of NAFLD risk.
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Cucoranu et al. (2023) conducted a cross-sectional in Non-Alcoholic Fatty Liver Disease (n=119). Abdominal anthropometric measurements (waist circumference and subcutaneous fat thickness) was evaluated on NAFLD risk (OR 11.45, p=<0.001). Higher baseline abdominal anthropometric measurements, particularly waist circumference (OR 11.45, p<0.001), were strongly correlated with liver attenuation and independently predicted NAFLD risk.
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