Key result
Each 1-unit increase in the atherogenic index of plasma was associated with a 45.3% higher risk of incident major adverse cardiovascular events (HR 1.453) in the general population.
Why the study?
It was unclear whether the atherogenic index of plasma is associated with major adverse cardiovascular events in the general population.
Does an elevated atherogenic index of plasma (AIP) increase the risk of incident major adverse cardiovascular events (MACEs) in the general population?
Cohort (n=361,644)
Yes
Does an elevated atherogenic index of plasma (AIP) increase the risk of incident major adverse cardiovascular events (MACEs) in the general population?
Answers are grounded in this paper and cite their sources.
Elevated atherogenic index of plasma (AIP) is an independent risk factor for incident MACEs in the general population, suggesting its potential utility in primary cardiovascular prevention.
It is unclear whether the atherogenic index of plasma (AIP) is associated with major adverse cardiovascular events (MACEs) in the general population. A total of 361,644 participants (aged 56.19 ± 8.09 years; 44.79% male) free of a history of MACEs at baseline from the UK Biobank data were included in the analysis. The AIP was calculated using log (triglyceride/high-density lipoprotein-cholesterol). Over a mean follow-up of 12.19 ± 1.60 years, 16,683 participants developed MACEs. After adjustment for traditional risk factors, each 1 unit increase in AIP was associated with a 45.3% higher risk of incident MACEs (hazard ratio (HR), 1.453 [95% confidence interval (CI) 1.371-1.540], P < 0.001). Results were similar when individuals were categorized by the AIP quartiles (HR, 1.283 [95% CI 1.217-1.351]; comparing extreme quartiles). The subgroup analyses showed that the association between AIP and risk of incident MACEs was more obvious in female participants who are < 60 years old and free of hypertension or diabetes. Sensitivity analysis included participants without any lipid-lowering medication or excluded incident MACEs in the first 2 years of follow-up confirming the robustness of the findings. Elevated AIP is a risk factor of incident MACEs in the general population, independent of traditional risk factors.Dynamic monitoring of the AIP may help select the population at high risk of cardiovascular events and guide primary prevention.
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Zhi et al. (2024) conducted a cohort in General population free of MACEs (n=361,644). Atherogenic index of plasma (AIP) vs. Lower AIP levels was evaluated on Incident major adverse cardiovascular events (MACEs) (HR 1.453, 95% CI 1.371-1.540, p=< 0.001). Each 1-unit increase in the atherogenic index of plasma was associated with a 45.3% higher risk of incident major adverse cardiovascular events (HR 1.453) in the general population.
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