We studied the clinical characteristics of 114 patients with therapy-related leukemia or therapy related myelodysplastic syndrome (t-Leuk/MDS). The mean age of the patients was 48 years. The Hematological malignancies were the most common primary (53%), followed by breast and ovarian cancer (30% combined). The mean latency until the development of t-Leuk/MDS was 45.5 months. Median survival was 10 months. Cytogenetics was abnormal in 89% of the patients. FLT3 internal tandem duplications were found in six of 41 (14.6%) patients, of whom four had an abnormal karyotype
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Rund et al. (2009) studied this question.