Why the study?
Clozapine is associated with myocarditis, but the optimal clinical signs, symptoms, and laboratory tests to alert clinicians accurately and earliest to presumptive myocarditis remained unclear.
Does initial exposure to clozapine compared to restarting clozapine increase the incidence of presumptive myocarditis in psychiatric patients?
Does initial exposure to clozapine compared to restarting clozapine increase the incidence of presumptive myocarditis in psychiatric patients?
Weekly troponin monitoring during the first 4 weeks of clozapine initiation is sensitive for detecting presumptive myocarditis, which occurred in 5.3% of initial exposures.
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Weekly troponin monitoring may enable early presumptive myocarditis detection during clozapine initiation; supports serial protocols but remains hypothesis-generating pending larger studies.
Surya et al. (2021) studied this question.
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