November 1, 1998Pacing and Clinical Electrophysiology
DDD Pacing with Rate Drop Response Function Versus DDI with Rate Hysteresis Pacing for Cardioinhibitory Vasovagal Syncope
Why the study?
Does DDD pacing with rate drop response function prevent syncope recurrence compared to DDI pacing with rate hysteresis in patients with cardioinhibitory vasovagal syncope?
Population
20 patients with recurrent syncope and cardioinhibitory responses during two head-up tilt tests
Comparison
DDD pacing with rate drop response function vs DDI pacing with rate hysteresis
Design
RCT, randomized, open trial
Follow-up
mean 17.7 +/- 7.4 months
Authors
Discussion
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Member takes
Implication
Supports DDD with rate drop response over DDI in cardioinhibitory vasovagal syncope; extends RCT evidence for pacing mode selection.
Structured PICO
Does DDD pacing with rate drop response function prevent syncope recurrence compared to DDI pacing with rate hysteresis in patients with cardioinhibitory vasovagal syncope?
P
Population
20 patients (12 males and 8 females; mean age 61.1 +/- 14 yrs) with recurrent syncope (mean number of prior episodes = 6.8) and cardioinhibitory responses during two head-up tilt tests (diagnostic and during drug therapy)
I
Intervention
DDD pacing with rate drop response function
C
Comparator
DDI pacing with rate hysteresis
O
Outcome
Recurrence of syncope during follow-uphard clinical
DDD pacing with rate drop response function significantly reduces the recurrence of syncope compared to DDI pacing with rate hysteresis in patients with cardioinhibitory vasovagal syncope.
Cite This Study
Ammirati et al. (1998) studied this question.