Nonsteroidal Anti-Inflammatory Drugs: Gastropathy, Deaths, and Medical Practice

Editorials1 September 1988Nonsteroidal Anti-Inflammatory Drugs: Gastropathy, Deaths, and Medical PracticeSanford H. Roth, MDSanford H. Roth, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-5-353 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNonsteroidal anti-inflammatory drugs (NSAIDs) have been commonly regarded as useful and relatively safe in treating painful musculoskeletal syndromes and disorders. There is a $2 billion worldwide market for these drugs, and more than 70 million prescriptions were written in the United States alone this past year. Therefore, the article by Griffin and colleagues (1) in this issue on NSAID use and death among elderly persons is actually part of a current of mounting experience, reports, and studies that has seriously challenged the safety of these agents as presently used in the practice of medicine (2).At the 22nd meeting of...References1. Griffin M, Ray W, and Schaffner W. Nonsteroidal anti-inflammatory drug use and death from peptic ulcer in elderly persons. Ann Intern Med. 1988;109:359-363. LinkGoogle Scholar2. Roth S. NSAID and gastropathy: a rheumatologist's review. J Rheum. 1988;15:912-919. MedlineGoogle Scholar3. . 22nd meeting of the Arthritis Advisory Committee of the U.S. Food and Drug Administration. Rockville, Maryland; 1988: May 16. Google Scholar4. Roth S and Bennett R. Nonsteroidal anti-inflammatory drug gastropathy: recognition and response. Arch Intern Med. 1987; 147:2093-100. CrossrefMedlineGoogle Scholar5. Sun D, Roth S, Mitchell C, and Englund D. Upper gastrointestinal disease in rheumatoid arthritis. Am J Dig Dis. 1974;19:405-10. CrossrefMedlineGoogle Scholar6. Graham D and Smith J. Aspirin and the stomach. Arch Intern Med. 1986;104:390-8. AbstractGoogle Scholar7. O'Laughlin J, Silvoso G, and Ivey K. Healing of aspirin-associated peptic ulcer disease despite continued salicylate ingestion. Arch Intern Med. 1981;141:781-3. CrossrefMedlineGoogle Scholar8. Hunt J and Fisher M. Aspirin-induced gastric bleeding stops despite rising plasma salicylate. Dig Dis Sci. 1980;25:135-9. CrossrefMedlineGoogle Scholar9. Roth S. Pharmacologic Approaches to Musculoskeletal Disorders. In: Hammerman D, ed. Clinics in Geriatric Medicine, v 4, n 2. Philadelphia: W.B. Saunders Co.; 1988:441-61. CrossrefGoogle Scholar10. Roth S, Bennett R, Mitchell C, and Hartman R. Cimetidine therapy in nonsteroidal anti-inflammatory drug gastropathy: double-blind long-term evaluation. Arch Intern Med. 1987:147:1798-801. CrossrefMedlineGoogle Scholar11. Szabo S and Pihan G. Mechanisms of gastric cytoprotection. J Clin Gastroenterol. 1987;9(Suppl 1):8-13. CrossrefMedlineGoogle Scholar12. Miller T. Protective agents of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. Am J Physiol. 1983;245(5 Pt 1):G601-23. MedlineGoogle Scholar13. Roth S, Agrawal N, and Mahowald M. Misoprostol heals aspirin induced gastropathy in rheumatoid arthritis [Abstract]. Arthritis Rheum. 1987;30(4):B16. Google Scholar14. Roth S. Nonsteroidal anti-inflammatory drug gastropathy [Editorial]. Arch Intern Med. 1986;146:1076. CrossrefGoogle Scholar15. Fries J. Postmarketing drug surveillance: are our priorities right? [Editorial]. J Rheum. 1988;15:389-90. MedlineGoogle Scholar16. Mitchell D, Spitz P, Young D, Bloch D, McShane D, and Fries J. Survival, prognosis, and causes of death in rheumatoid arthritis. Arthritis Rheum. 1986;29:706-14. CrossrefMedlineGoogle Scholar17. Wolfe F, Kleinheksel S, and Spitz P. A multicenter study of hospitalization in rheumatoid arthritis: frequency, medical-surgical admission, and charges. Arthritis Rheum. 1986;29:614-9. CrossrefMedlineGoogle Scholar18. Roth S. NSAIDS: risk benefit vs. cost benefit. Proceedings of the Drug Information Association Meeting, Hilton Head, South Carolina, March 1988. Drug Inform J. 1988;22: [In press]. CrossrefGoogle Scholar19. Roth S. Salicylates. In: Katz WA, ed. Management of Rheumatic Disease. 2nd ed. Philadelphia: J.B. Lippincott: [In press]. Google Scholar20. Roth S. Endoscopic comparison of the tolerance and safety of carprofen and ibuprofen in patients with rheumatoid arthritis [Abstract]. Proceedings of the IX Pan American Congress of Rheumatology Meeting, Buenos Aires, Argentina, 1986. Atlanta: American Rheumatism Association; 1986. Google Scholar21. Lawson D. Scientific problems in collecting and analysing safety data in nonexperimental studies. Drug Inform J. 1988;22:11-8. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Sanford H. 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Scarlett, MDMerits and Liabilities of NSAID TherapyPeptic ulcer in rheumatoid arthritis.Incidence of Gastropathy in Destructive ArthropathiesNew Understandings of NSAID Gastropathy 1 September 1988Volume 109, Issue 5 Page: 353-354 Keywords Drugs Elderly Gastroenterology and hepatology NSAIDs Safety Safety studies ePublished: 1 December 2008 Issue Published: 1 September 1988 PDF downloadLoading ...