Why the study?
Do quantitative D-dimer assays with age-specific cut-offs improve the prediction of recurrent venous thromboembolism risk compared to qualitative assays in patients after cessation of vitamin K antagonism?
Population
321 patients with venous thromboembolism enrolled in the PROLONG study, evaluated 30+/-10 days after…
Comparison
Quantitative D-dimer assays using age-specific… vs Qualitative D-dimer assay
Design
Cohort
Authors
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May enhance post-VKA recurrence risk stratification; leaves open superiority of quantitative age-specific over qualitative D-dimer assays.
Do quantitative D-dimer assays with age-specific cut-offs improve the prediction of recurrent venous thromboembolism risk compared to qualitative assays in patients after cessation of vitamin K antagonism?
Quantitative D-dimer assays with age-specific cut-offs may better stratify the risk of recurrent venous thromboembolism after stopping anticoagulation, particularly in elderly patients.
Legnani et al. (2008) studied this question.
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