Why the study?
Does Radix Paeoniae Rubra extract and its active compounds prevent thrombus formation in an acute blood stasis rat model?
Does Radix Paeoniae Rubra extract and its active compounds prevent thrombus formation in an acute blood stasis rat model?
Radix Paeoniae Rubra extract and its active compounds demonstrate antithrombotic properties in a rat model, suggesting potential as a natural anticoagulant therapy.
RPR compounds show antithrombotic activity in rats; leaves open translation to human thrombosis management.
The compounds of Radix Paeoniae Rubra (RPR) were isolated and identified by bioassay-guided method, and antithrombotic effects and mechanism were investigated by the acute blood stasis rat model. The RPR extract was evaluated by APTT, TT, PT, and FIB assays in vitro. Results indicated that RPR extract exhibited the anticoagulant activity. In order to find active compounds, six compounds were isolated and identified, and four compounds, paeoniflorin (Pae), pentagalloylglucose (Pen), albiflorin (Ali), and protocatechuic acid (Pro), exhibited the anticoagulant activity in vitro. Therefore, the antithrombosis effects of RPR extract and four active compounds were investigated in vivo by measuring whole blood viscosity (WBV), plasma viscosity (PV), APTT, PT, TT, and FIB. Meanwhile, the levels of TXB 2 , 6-Keto-PGF 1 α , eNOS, and ET-1 were detected. Results suggested that RPR extract and four active compounds had the inhibition effect on thrombus formation, and the antithrombotic effects were associated with the regulation of vascular endothelium active substance, activating blood flow and anticoagulation effect.
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Xie et al. (2017) studied this question.
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