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Acidic proteins from cell nuclei of rat brain were evaluated by gel electrophoresis. By the use of a gel containing a high ratio of bis‐acrylamide to acrylamide, 31 bands were demonstrated for this protein fraction. Gels without the high concentration of copolymer lacked the resolving power to separate these proteins. Because the number of bands present in the acidic protein fraction is greater than the number of histones present in cell nuclei, the suggestion that the acidic proteins play a role in genetic regulation seems reasonable.
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Davis et al. (1972) studied this question.
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