Highlights that ACE inhibitor-induced angioedema can occur as a delayed adverse event, even after 14 months of therapy.
Late-onset ACE inhibitor angioedema remains possible; this case extends the documented onset window and leaves optimal surveillance duration open.
The angiotensin-converting enzyme inhibitors have gained widespread application in the management of hypertension and congestive heart failure, and after myocardial infarction. They are generally considered safe drugs, but there are a number of reports of angioedema associated with their use. In general, angioedema occurs within hours to days after initiation of therapy, and only a limited number of reports document a delayed onset. Our patient experienced angioedema after 14 months of therapy with benazepril.
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O’Mara et al. (1996) studied this question.