What question did this study set out to answer?

Identify sources of artifactual false-positive echocardiographic diagnoses and determine the inheritance pattern and familial prevalence of mitral valve prolapse.

December 1, 1975CirculationOpen Access

Echocardiographic detection of mitral valve prolapse. Exclusion of false positive diagnosis and determination of inheritance.

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Why the study?

What is the mode of inheritance and familial prevalence of mitral valve prolapse when evaluated with a specific echocardiographic technique?

Population

74 subjects, composed of 57 first-degree relatives and 17 propositi with mitral valve prolapse

Design

Cross-sectional

Authors

AWAlan N. WeissCedars-Sinai Medical Center JMJames W. MimbsWashington University in St. Louis PLP A LudbrookWashington University in St. Louis

Discussion

Member takes

Implication

Supports screening first-degree relatives; leaves open confirmation of autosomal dominant inheritance with reduced male expressivity in prospective studies.

Key Points

Identify sources of artifactual false-positive echocardiographic diagnoses and determine the inheritance pattern and familial prevalence of mitral valve prolapse.
Evaluated 74 subjects, comprising 17 propositi with mitral valve prolapse and 57 of their first-degree relatives.
Employed a modified echocardiographic technique to eliminate artifactual systolic hammock patterns produced by inferior angulation of the ultrasound transducer.
Mitral valve prolapse was identified in 27 of 57 (47%) first-degree relatives, including 53% of female progeny and 36% of male progeny.
Transmission from propositi to offspring of both sexes occurred in an autosomal dominant mode with reduced male expressivity.

Structured PICO

What is the mode of inheritance and familial prevalence of mitral valve prolapse when evaluated with a specific echocardiographic technique?

Population

74 subjects, composed of 57 first-degree relatives and 17 propositi with mitral valve prolapse

Intervention

Modified, more specific echocardiographic technique

Outcome

Mode of inheritance and familial prevalence of mitral valve prolapse

Mitral valve prolapse is transmitted in an autosomal dominant mode with reduced male expressivity, and specific echocardiographic techniques are required to avoid false positive diagnoses.

Cite This Study

Weiss et al. (1975) studied this question.

synapsesocial.com/papers/6a7a7cc9b9dd6cc1fe0dbd30 https://doi.org/10.1161/01.cir.52.6.1091

Topics

Mitral valve intervention Echocardiography

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Implication

Supports screening first-degree relatives; leaves open confirmation of autosomal dominant inheritance with reduced male expressivity in prospective studies.

Echocardiographic detection of mitral valve prolapse. Exclusion of false positive diagnosis and determination of inheritance.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Echocardiographic detection of mitral valve prolapse. Exclusion of false positive diagnosis and determination of inheritance.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider