Why the study?
Do coronary collateral channels provide myocardial protection in patients sustaining myocardial infarction?
Do coronary collateral channels provide myocardial protection in patients sustaining myocardial infarction?
Coronary collateral channels appear to offer myocardial protection during infarction, though the mechanisms stimulating their development remain debated.
May support collateral assessment for MI risk stratification; leaves open therapeutic targeting.
This section describes the clinical evidence for benefit from coronary collateral channels. There is data to suggest the presence of a protective effect in patients sustaining myocardial infarction regardless of whether they receive reperfusion therapy, and whether the collaterals were preformed. The role of pre-infarction angina in stimulating collateral development remains a contentious issue.
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Smith et al. (2004) studied this question.
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