Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis

April 7, 2025Protein & CellOpen Access

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Key Points

This research aims to explore the role of dynamin 1 in the endocytic recycling of N-cadherin and its implications for metastatic behavior in ovarian cancer.
Employ master regulator algorithm to analyze 8,000+ patient samples from TCGA.
Conduct in vitro assays to evaluate DNM1 expression in ovarian cancer cell lines and its correlation with EMT markers.
Analyze the impact of DNM1 knockdown and overexpression on cell migration and N-cadherin dynamics in ovarian cancer cells.
Higher DNM1 levels correlate with N-cadherin expression and poor survival outcomes in ovarian cancer patients (P<0.01).
DNM1 knockdown led to reduced migration and altered N-cadherin recycling in metastatic cell lines (P<0.05).
Overexpression of DNM1 in non-metastatic cells induced EMT features and enhanced their migratory capacity.

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Investigates how dynamin 1 influences N-cadherin recycling and metastasis in ovarian cancer, suggesting novel therapeutic targets.

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Cai et al. (2025) studied this question.

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