Population
Cultured bovine pulmonary artery endothelial cells
Design
Preclinical
Authors
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Findings in bovine cells warrant caution before human extrapolation; leaves open in vivo validation of second-messenger calcium pathways.
In cultured bovine pulmonary artery endothelial cells, bradykinin increases cytosolic calcium likely via a second messenger system rather than a receptor-operated non-selective cation channel.
Cannell et al. (1989) studied this question.
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