On the Possible Role of Bradykinin in Functional Hyperemia of Cat's Stomach

F asth , S. and J. M artinson . On the possible role of bradykinin in functional hyperemia of cat's stomach. Acta physiol. scand. 1973. 89. 334–341. The reactions of the consecutive vascular sections of the stomach were studied with a plethysmography technique at “rest”, during graded and maximal vasodilatation induced by isoprenaline and during infusion of bradykinin, supposed to be involved in functional hyperemia evoked by vagal nerve stimulation. It is shown that the stomach has a great capacity to maintain a rather constant area for filtration even during large variations in peripheral resistance. Bradykinin evoked an atropine resistant vasodilatation. This is similar to the effect of vagal stimulation. In contrast bradykinin did not increase capillary permeability which is one effect recognized for vagal stimulation. It is concluded that this plasmakinin may not play a role of mediator of functional hyperemia in the stomach since the whole pattern of vascular effects known for vagal stimulation is not reproduced.