What question did this study set out to answer?

To determine the intrinsic mechanisms responsible for elevated intestinal vascular resistance during increased venous pressure.

November 1, 1959Circulation ResearchOpen Access

Myogenic Nature of Increase in Intestinal Vascular Resistance with Venous Pressure Elevation

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To determine the intrinsic mechanisms responsible for elevated intestinal vascular resistance during increased venous pressure.
Assessed the venous-arteriolar response during local neural blockade using intra-arterial procaine infusion.
Evaluated vascular resistance alterations following smooth muscle relaxation with papaverine, metabolic inhibition with cyanide and ischemia, and non-physiological perfusion with an oil-kerosene mixture.
Procaine infusion failed to prevent the resistance increase, whereas papaverine significantly attenuated the response, and metabolic inhibition via cyanide or ischemia abolished it completely.
Oil-kerosene perfusion decreased vascular resistance during venous pressure elevation despite fluid accumulation matching blood-perfused controls.

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Implication

Experimental study demonstrates that venous pressure elevation increases intestinal vascular resistance via myogenic constriction, indicating an intrinsic muscular rather than neural mechanism.

Cite This Study

Johnson et al. (1959) studied this question.

synapsesocial.com/papers/6a7a8a8cf8c4f08607027e44 https://doi.org/10.1161/01.res.7.6.992

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Implication

Experimental study demonstrates that venous pressure elevation increases intestinal vascular resistance via myogenic constriction, indicating an intrinsic muscular rather than neural mechanism.

Myogenic Nature of Increase in Intestinal Vascular Resistance with Venous Pressure Elevation

Key Points

Discussion

Implication

Cite This Study

Myogenic Nature of Increase in Intestinal Vascular Resistance with Venous Pressure Elevation

Key Points

Discussion

Implication

Cite This Study

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