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High Resolution Image Download MS PowerPoint Slide Coordination of FeCl 3 to the redox-active pyridine–aminophenol ligand NNO H2 in the presence of base and under aerobic conditions generates FeCl 2 ( NNO ISQ ) ( 1 ), featuring high-spin Fe III and an NNO ISQ radical ligand. The complex has an overall S = 2 spin state, as deduced from experimental and computational data. The ligand-centered radical couples antiferromagnetically with the Fe center. Readily available, well-defined, and air-stable 1 catalyzes the challenging intramolecular direct C(sp 3 )–H amination of unactivated organic azides to generate a range of saturated N-heterocycles with the highest turnover number (TON) (1 mol% of 1, 12 h, TON = 62; 0.1 mol% of 1, 7 days, TON = 620) reported to date. The catalyst is easily recycled without noticeable loss of catalytic activity. A detailed kinetic study for C(sp 3 )–H amination of 1-azido-4-phenylbutane ( S 1 ) revealed zero order in the azide substrate and first order in both the catalyst and Boc 2 O. A cationic iron complex, generated from the neutral precatalyst upon reaction with Boc 2 O, is proposed as the catalytically active species.
Bagh et al. (Wed,) studied this question.