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Recently, the development of rotaxane-based architectures for biological applications has started to attract interest. In this short review, we summarize the main advances that have been realized in this burgeoning area of research, including the design of squaraine-rotaxane dyes for optical bioimaging applications, host-rotaxanes as cellular transport agents, enzyme-responsive rotaxanes and mechanized mesoporous silica nanoparticles coated with “nanovalves” as drug delivery systems.
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Pairault et al. (2016) studied this question.
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