Why the study?
Because aspirin's adverse effects are dose-dependent and evidence supporting low-dose aspirin for VTE prevention after THA is weak, the minimal effective dosage remains unknown.
Does low-dose aspirin prevent VTE as effectively as high-dose aspirin in healthy patients following total joint arthroplasty?
Does low-dose aspirin prevent VTE as effectively as high-dose aspirin in healthy patients following total joint arthroplasty?
Low-dose aspirin (81 mg BID) is as effective as high-dose aspirin (325 mg BID) for VTE prophylaxis following total joint arthroplasty, with a similar safety profile.
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Low-dose aspirin may suffice for post-arthroplasty VTE prophylaxis in healthy patients; leaves open whether it reduces complications versus high-dose regimens.
Shafiei et al. (2023) studied this question.
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