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March 1, 2002AJP Renal Physiology

Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B12

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Authors

HBHenrik BirnTWThomas E. WillnowRNRikke Nielsen

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Birn et al. (2002) studied this question.

synapsesocial.com/papers/6a7a96f79092edbae3f3af32https://doi.org/10.1152/ajprenal.00206.2000
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evidence for an Essential Role of Megalin in Transepithelial Transport of Retinol1999 · 244 citations
  2. 2Studies on transcobalamin (TC). 1. Detection of TC II isoproteins in human serum1979 · 51 citations
  3. 3Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis.1996 · 216 citations
  4. 4Characterization of a 280-kD protein restricted to the coated pits of the renal brush border and the epithelial cells of the yolk sac. Teratogenic effect of the specific monoclonal antibodies.1988 · 138 citations
  5. 5Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein.1992 · 147 citations