What question did this study set out to answer?

Identify underlying genetic alterations and oncogenic drivers in breast implant-associated anaplastic large cell lymphoma.

May 19, 2016HaematologicaOpen Access

Whole exome sequencing reveals activating JAK1 and STAT3 mutations in breast implant-associated anaplastic large cell lymphoma anaplastic large cell lymphoma

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Authors

PBPiers BlomberyThe Royal Melbourne Hospital ETElla R. ThompsonThe Royal Melbourne Hospital KJKate JonesPeter MacCallum Cancer Centre

Discussion

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Implication

Genomic analysis uncovers activating JAK1 and STAT3 mutations in breast implant-associated lymphoma, suggesting a critical role for JAK-STAT signaling.

Key Points

Identify underlying genetic alterations and oncogenic drivers in breast implant-associated anaplastic large cell lymphoma.
Performed whole exome sequencing on breast implant-associated anaplastic large cell lymphoma specimens to characterize somatic genomic mutations.
Revealed activating mutations occurring within the JAK1 and STAT3 genes.
Identified constituent involvement of the JAK-STAT signaling pathway in lymphoma pathogenesis.

Cite This Study

Blombery et al. (2016) studied this question.

synapsesocial.com/papers/6a7aa066e357fbdac5899819 https://doi.org/10.3324/haematol.2016.146118

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Implication

Genomic analysis uncovers activating JAK1 and STAT3 mutations in breast implant-associated lymphoma, suggesting a critical role for JAK-STAT signaling.

Whole exome sequencing reveals activating JAK1 and STAT3 mutations in breast implant-associated anaplastic large cell lymphoma anaplastic large cell lymphoma

Discussion

Member takes

Implication

Key Points

Cite This Study

Whole exome sequencing reveals activating JAK1 and STAT3 mutations in breast implant-associated anaplastic large cell lymphoma anaplastic large cell lymphoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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