Why the study?
Type 2 diabetes mellitus is a major risk factor worsening heart failure prognosis and increasing fatal cardiovascular events through diverse atherogenic, neurohumoral, molecular, and histological mechanisms.
Answers are grounded in this paper and cite their sources.
This review summarizes the complex pathogenic mechanisms, including metabolic and epigenetic changes, driving heart failure development and progression in patients with type 2 diabetes.
Highlights The review presents up-to-date data on the contribution of type 2 diabetes mellitus to the development and progression of heart failure. The review highlights the key mechanisms of the pathogenesis of heart failure associated with changes in the energy metabolism of cardiomyocytes. Abstract Type 2 diabetes mellitus is one of the main risk factors that significantly worsen the prognosis of heart failure and increases the probability of fatal cardiovascular events. The development of heart failure in diabetic patients involves a great number of risk factors for the rapid progression of atherosclerosis, as well as numerous combinations of neurohumoral, molecular and histological changes not associated with atherogenesis, which interconnection results in cardiovascular complications and heart failure decompensation. This review discusses the key mechanisms underlying development of heart failure in type 2 diabetes mellitus, in particular, special attention is paid to cardiomyocyte energy metabolism, cardiomyocyte death, and the significance of epigenetic factors in progression of chronic heart failure.
No takes yet. Share an insight, caveat, or question.
Иванченко et al. (2023) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: