Why the study?
Does prothrombin complex concentrate reverse the anticoagulant effect of fondaparinux and reduce bleeding in a rabbit model?
Population
Anaesthetised and ventilated rabbits subjected to the Folts model
Comparison
Prothrombin complex concentrate 40 UI.kg-1… vs Control and fondaparinux alone
Design
Preclinical, Randomised into three groups after the first cyclic flow reduction
Follow-up
15 minutes post-hepatosplenic section
Authors
Loading...
Reverses fondaparinux bleeding without thrombosis in rabbits; leaves open human translation.
Does prothrombin complex concentrate reverse the anticoagulant effect of fondaparinux and reduce bleeding in a rabbit model?
In a rabbit model, prothrombin complex concentrate effectively reversed the hemorrhagic effects of fondaparinux without increasing thrombosis.
Durand et al. (2010) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: