Why the study?
AF is partially heritable, but a substantial proportion of heritability remains unexplained.
Bioinformatic analysis of public microarray datasets identified 9 potential crucial genes, notably CXCR4, IGFBP2, IGFBP3, and FHL2, that may be associated with the risk and molecular pathogenesis of atrial fibrillation.
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May inform targeted AF gene studies; leaves open clinical translation pending validation.
Zhang et al. (2020) studied this question.
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