Why the study?
Does pulmonary capillary endothelium-bound ACE activity correlate with the severity of acute lung injury in mechanically ventilated critically ill patients?
Population
33 mechanically ventilated, critically ill patients with a lung injury score ranging from 0 to 3.7
Design
Cross-sectional
Authors
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ACE activity reduction was associated with ALI severity; hypothesis-generating for biomarker utility, should not yet change practice.
Does pulmonary capillary endothelium-bound ACE activity correlate with the severity of acute lung injury in mechanically ventilated critically ill patients?
Pulmonary capillary endothelium-bound ACE activity decreases early in acute lung injury and correlates with clinical severity, suggesting its potential as a quantifiable marker of pulmonary capillary endothelial dysfunction.
Orfanos et al. (2000) studied this question.
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