What question did this study set out to answer?

To evaluate the current clinical evidence regarding the efficacy and effectiveness of influenza vaccines in reducing confirmed influenza and influenza-like illness in HIV-infected individuals.

September 11, 2006BMC Infectious DiseasesOpen Access

Efficacy and clinical effectiveness of influenza vaccines in HIV-infected individuals: a meta-analysis

View Full Paper

Ask AI

Bookmark

Authors

JAJulius AtashiliUniversity of North Carolina at Chapel Hill LKLinda KalilaniUniversity of North Carolina at Chapel Hill AAAdaora A. AdimoraUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Meta-analysis reveals reduced influenza incidence following vaccination in HIV-infected individuals, indicating moderate vaccine effectiveness despite limited overall trial evidence.

Key Points

To evaluate the current clinical evidence regarding the efficacy and effectiveness of influenza vaccines in reducing confirmed influenza and influenza-like illness in HIV-infected individuals.
Systematically searched electronic databases for studies comparing the incidence of laboratory-confirmed influenza or influenza-like illness between vaccinated and unvaccinated HIV patients.
Extracted study characteristics and calculated risk differences (RD), numbers needed to vaccinate (NNV), and vaccine effectiveness (VE) across comparative cohorts (N=646) using a random effects model.
Vaccination significantly reduced influenza risk across four comparative studies (N=646), yielding a pooled summary RD of -0.27 (95% CI: -0.42 to -0.11).
Individual study risk differences ranged from -0.48 (95% CI: -0.63 to -0.34) to -0.15 (95% CI: -0.25 to 0.05), corresponding to vaccine effectiveness estimates between 27% and 78%.
The number needed to vaccinate to prevent a single case of influenza ranged from 3 to 7 individuals, with no evidence of publication bias observed.

Cite This Study

Atashili et al. (2006) studied this question.

synapsesocial.com/papers/6a7aa8f0684c0941cf324c4d https://doi.org/10.1186/1471-2334-6-138

View Full Paper

Ask AI

Bookmark

Implication

Meta-analysis reveals reduced influenza incidence following vaccination in HIV-infected individuals, indicating moderate vaccine effectiveness despite limited overall trial evidence.

Efficacy and clinical effectiveness of influenza vaccines in HIV-infected individuals: a meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Efficacy and clinical effectiveness of influenza vaccines in HIV-infected individuals: a meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider