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June 10, 2020Open Access

Exercise as a complementary therapy for depression: a systematic review and meta-analysis of randomized controlled trials and bioinformatics exploration gene network model .

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Why the study?

The effects of pharmacological treatment, exercise treatment, and their combination on depressive symptoms remain a matter of debate.

Does exercise treatment, alone or with pharmacological therapy, reduce depressive symptoms in depressive patients?

Population

Depressive patients across 15 randomized controlled trials

Comparison

Exercise treatment with or without pharmacological treatment vs control group

Design

Systematic review, meta-analysis of RCTs, and in silico bioinformatics exploration

Authors

LCLara CarneiroAl Ain UniversityFSFelipe SilvaPontificia Universidad Católica de ChileJVJosé Vasoncelos-Raposo

Discussion

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Implication

Supports adding supervised exercise to pharmacotherapy for depression; extends dose-response evidence from RCTs for optimized prescriptions.

Structured PICO

Does exercise treatment, alone or with pharmacological therapy, reduce depressive symptoms in depressive patients?

P
Population
Depressive patients from 15 randomized controlled trials
I
Intervention
Exercise treatment (ET) as monotherapy or complementary to pharmacological therapy (PT)
C
Comparator
Control group
O
Outcome
Change in depressive symptoms measured by validated depression scales (pre and post-intervention)patient reported

Exercise treatment combined with pharmacological therapy significantly reduces depressive symptoms, with resistance training and specific aerobic exercise parameters showing optimal dose-response.

Limitations

  • More well-designed studies are needed to confirm our findings

Cite This Study

Carneiro et al. (2020) studied this question.

synapsesocial.com/papers/6a7aaba01b9920df6d895d80https://doi.org/10.21203/rs.3.rs-24600/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Epidemiology of Depression Across Cultures2013 · 2,749 citations
  2. 2Exercise parameters in the treatment of clinical depression: a systematic review of randomized controlled trials2009 · 142 citations
  3. 3Treating Major Depression with Physical Activity: A Systematic Overview with Recommendations2015 · 113 citations
  4. 4STRING v9.1: protein-protein interaction networks, with increased coverage and integration2012 · 4,585 citations
  5. 5Internet-delivered therapist-guided physical activity for mild to moderate depression: a randomized controlled trial2013 · 66 citations