July 25, 2013Clinical Science
Combining risk markers improves cardiovascular risk prediction in women
Why the study?
Does the addition of non-invasive risk markers to traditional risk factors improve cardiovascular risk prediction in middle-aged CVD-free individuals?
Population
1367 CVD-free participants aged 50-70 years old from a middle-aged population-based cohort.
Comparison
Addition of non-invasive risk markers… vs Traditional cardiovascular risk factors alone.
Design
Cohort
Follow-up
mean 3.8 years
Authors
Discussion
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Member takes
Implication
May support carotid ultrasound for reclassification in women; leaves open prospective validation before clinical use.
Structured PICO
Does the addition of non-invasive risk markers to traditional risk factors improve cardiovascular risk prediction in middle-aged CVD-free individuals?
P
Population
1367 CVD-free participants aged 50-70 years old from a middle-aged population-based cohort.
I
Intervention
Addition of non-invasive risk markers (carotid-plaques, IMT, ABI, PWV, AIx, CAP, CSP) individually or combined to traditional risk scores.
C
Comparator
Traditional cardiovascular risk factors alone.
O
Outcome
Cardiovascular events and risk reclassification (measured by AUC and NRI) at mean 3.8 years follow-up.hard clinical
Adding combined non-invasive risk markers, particularly carotid ultrasound measures, significantly improves cardiovascular risk reclassification in women, with more limited benefit in intermediate-risk men.
Cite This Study
Holewijn et al. (2013) studied this question.