Experimental study demonstrates a catalyst-free multicomponent synthesis of aromatic aminoalkyl amines via carbon-nitrogen cleavage, indicating a streamlined route to bioactive molecules.
An intriguing C-N transformation involving a catalyst-free N-alkylation/N'-arylation process in a multicomponent reaction with secondary amines, cyclic tertiary amines and electron-deficient aryl halides has been described. In this case, the N-alkylation of secondary amines, utilizing cyclic tertiary amines as alkyl group sources, is enabled by a facile C-N cleavage. Such an operationally simple method could facilitate access to aromatic aminoalkyl amines, nitrogen-containing bioactive molecules, in good to excellent yields.
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Zhu et al. (2018) studied this question.
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