February 28, 1994FEBS Letters

Deletion of highly conserved C‐terminal sequences in the Kv1 K+ channel sub‐family does not prevent expression of currents with wild‐type characteristics

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Population

Mouse L-cells expressing human Kv1.5 channel and rat Kv1.1 channel

Comparison

Deletions of the 4, 16, and 57 C-terminal… vs Wild-type Kv1.5 and Kv1.1 channels

Design

Preclinical

Authors

VUVictor N. UebeleUnited States Military Academy SYSarita YeolaBristol-Myers Squibb (Germany)DSDirk J. SnydersUniversity of Antwerp

Discussion

Member takes

Implication

C-terminal residues are dispensable for Kv1.5 function in vitro; leaves open roles in native cardiomyocytes or arrhythmia models.

Structured PICO

Population

Mouse L-cells expressing human Kv1.5 channel and rat Kv1.1 channel

Intervention

Deletions of the 4, 16, and 57 C-terminal residues (including the conserved (E/L)TDV motif)

Comparator

Wild-type Kv1.5 and Kv1.1 channels

Outcome

Whole cell current amplitude, midpoint of activation, degree of inactivation, and activation kineticssurrogate

The highly conserved C-terminal (E/L)TDV motif and most C-terminal amino acids are not required for the functional expression and normal gating characteristics of Kv1 potassium channels.

Cite This Study

Uebele et al. (1994) studied this question.

synapsesocial.com/papers/6a7ac320b2ad017e4032315c https://doi.org/10.1016/0014-5793(94)80181-9

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Deletion of highly conserved C‐terminal sequences in the Kv1 K+ channel sub‐family does not prevent expression of currents with wild‐type characteristics

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Deletion of highly conserved C‐terminal sequences in the Kv1 K+ channel sub‐family does not prevent expression of currents with wild‐type characteristics

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider