Biologic effectiveness increases with earlier biologic initiation after severe asthma onset

Background: Patients with long-standing, uncontrolled, severe asthma can develop airway fibrosis and remodeling due to chronic inflammation, causing irreversible pulmonary damage. Objective: This analysis evaluated the effect of the time from severe asthma onset to initiation of a biologic on treatment effectiveness in US patients with subspecialist-treated severe asthma. Conclusion: With adjustment for factors including prior exacerbations and race, a shorter time from severe asthma onset to initiation of a biologic was associated with a lower rate of exacerbation during treatment and increased effectiveness of treatment with a biologic.