What question did this study set out to answer?

This study evaluates the concordance between flow cytometry and NGS-based assays for monitoring measurable residual disease (MRD) in adult B-cell acute lymphoblastic leukemia (B-ALL).

August 11, 2026International Journal of Laboratory Hematology

Laboratory Concordance and Prognostic Impact of 10‐Color Flow Cytometry and Next‐Generation Sequencing‐Based Immunoglobulin Gene Assay for Measurable Residual Disease Monitoring in Adult B‐Cell Acute Lymphoblastic Leukemia: A Multicenter Study From Thai Acute Leukemia Working Group ( TALWG )

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Authors

CCChantiya ChanswangphuwanaChulalongkorn University WLWasithep LimvorapitakThammasat University SKSirorat KobbuakleeChulalongkorn University

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Implication

Randomized trial assesses measurable residual disease detection methods in adult B-ALL, suggesting their significance for patient’s prognosis.

Key Points

This study evaluates the concordance between flow cytometry and NGS-based assays for monitoring measurable residual disease (MRD) in adult B-cell acute lymphoblastic leukemia (B-ALL).
Multicenter prospective study involving 51 newly diagnosed B-ALL patients.
Bone marrow samples analyzed at diagnosis, post-induction, and post-early consolidation for MRD detection using both flow cytometry and NGS-IGH.
Assessed prognostic significance and associated treatment protocols including chemotherapy and hematopoietic cell transplantation.
Overall concordance between flow cytometry and NGS was 80.7%.
MRD negativity at 3 months correlated with significantly superior relapse-free survival (RFS).
Flow cytometry MRD positivity at 3 months independently predicted inferior RFS (HR 3.81; 95% CI 1.01–14.43).

Cite This Study

Chanswangphuwana et al. (2026) studied this question.

synapsesocial.com/papers/6a7ace273401087f2249df16 https://doi.org/10.1111/ijlh.70216

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Implication

Randomized trial assesses measurable residual disease detection methods in adult B-ALL, suggesting their significance for patient’s prognosis.

Laboratory Concordance and Prognostic Impact of 10‐Color Flow Cytometry and Next‐Generation Sequencing‐Based Immunoglobulin Gene Assay for Measurable Residual Disease Monitoring in Adult B‐Cell Acute Lymphoblastic Leukemia: A Multicenter Study From Thai Acute Leukemia Working Group ( TALWG )

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Cite This Study

Laboratory Concordance and Prognostic Impact of 10‐Color Flow Cytometry and Next‐Generation Sequencing‐Based Immunoglobulin Gene Assay for Measurable Residual Disease Monitoring in Adult B‐Cell Acute Lymphoblastic Leukemia: A Multicenter Study From Thai Acute Leukemia Working Group ( TALWG )

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