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August 11, 2026PharmaceuticalsOpen Access

Semaglutide Exposure During Pregnancy: Results from the FAERS Database

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Authors

AZAlessia ZinziRegione CampaniaMGMario GaioRegione CampaniaAMAnnamaria MascoloRegione Campania

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Implication

Post-marketing study reports pregnancy outcomes related to semaglutide use, indicating potential risks.

Key Points

  • This research aims to evaluate the safety profile of semaglutide during pregnancy by analyzing adverse events reported in the FAERS database.
  • Conducted a post-marketing analysis using the FAERS database from 2017–2025.
  • Performed descriptive analyses on pregnancy outcomes and fetal/neonatal disorders.
  • Executed disproportionality analyses to assess adverse event reporting by System Organ Class.
  • Identified 249 cases of semaglutide use during pregnancy, with 922 reported adverse events.
  • Higher reporting odds were found for termination of pregnancy (ROR 3.71; 95% CI 3.07–4.48) and other pregnancy-related complications.
  • No significant association observed for congenital anomalies or reproductive disorders.

Cite This Study

Zinzi et al. (2026) studied this question.

synapsesocial.com/papers/6a7ace343401087f2249e182https://doi.org/10.3390/ph19081249
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