What question did this study set out to answer?

To evaluate the antitumor efficacy and mechanistic actions of the herbal compound tetrandrine in human acute promyelocytic leukemia cells.

March 10, 2015OncotargetOpen Access

Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells

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Authors

TLTing LiuQingdao University QMQiuxu MenWuhan University GWGuixian WuArmy Medical University

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Implication

Experimental study demonstrates tetrandrine triggers autophagy and differentiation in acute promyelocytic leukemia cells, suggesting a potential alternative differentiating therapy.

Key Points

To evaluate the antitumor efficacy and mechanistic actions of the herbal compound tetrandrine in human acute promyelocytic leukemia cells.
Tested tetrandrine in human PML-RARα-positive acute promyelocytic leukemia cell lines and M5 subtype primary patient leukemia cells.
Assessed in vivo tumor inhibition and evaluated in vitro cell proliferation, differentiation markers, and autophagy induction.
Analyzed the involvement of reactive oxygen species (ROS) production and Notch1 signaling pathway activation.
Tetrandrine significantly inhibited leukemia tumor growth in vivo and suppressed leukemia cell proliferation at low concentrations.
Tetrandrine treatment induced cellular autophagy and promoted differentiation in both PML-RARα-positive cells and primary M5 patient leukemia cells.
Autophagy and cell differentiation were mediated by the upregulation of ROS generation and subsequent activation of Notch1 signaling.

Cite This Study

Liu et al. (2015) studied this question.

synapsesocial.com/papers/6a7acedfe9a465269f0de8fe https://doi.org/10.18632/oncotarget.3505

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Implication

Experimental study demonstrates tetrandrine triggers autophagy and differentiation in acute promyelocytic leukemia cells, suggesting a potential alternative differentiating therapy.

Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells

Discussion

Member takes

Implication

Key Points

Cite This Study

Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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