Why the study?
Does intracoronary vasodilation with prazosin or adenosine improve myocardial contractile function during submaximal exercise in a canine model?
Population
6 chronically instrumented dogs undergoing submaximal exercise
Comparison
Intracoronary prazosin or adenosine through an… vs Exercise alone
Design
Preclinical
Authors
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Does not change clinical practice; leaves open whether flow limits contractility during exercise in humans.
Does intracoronary vasodilation with prazosin or adenosine improve myocardial contractile function during submaximal exercise in a canine model?
Intracoronary vasodilation with prazosin or adenosine during submaximal exercise increases coronary blood flow and improves myocardial contractile function in a canine model, suggesting contractile function may be flow-limited during exercise.
Gwirtz et al. (1990) studied this question.
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