What question did this study set out to answer?

To identify the signaling cascades downstream of E-selectin ligands that mediate integrin alpha(L)beta(2)-dependent slow neutrophil rolling.

March 18, 2010BloodOpen Access

E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin αLβ2-mediated slow leukocyte rolling

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To identify the signaling cascades downstream of E-selectin ligands that mediate integrin alpha(L)beta(2)-dependent slow neutrophil rolling.
Assessed molecular signaling downstream of PSGL-1 and CD44 engagement by E-selectin in neutrophils, focusing on lipid rafts, cytoplasmic domains, and kinase intermediates.
Evaluated slow leukocyte rolling and cell recruitment in vivo using inflamed venule models in mice.
Engagement of either PSGL-1 or CD44 by E-selectin triggered slow rolling through a common lipid raft-dependent pathway utilizing the Src family kinases Hck, Lyn, and Fgr.
Bruton tyrosine kinase acted as an essential signaling intermediate between Syk and p38 to mediate slow rolling.
Slow rolling required the cytoplasmic domain of PSGL-1 to activate Src family kinases, but operated independently of phosphoinositide-3-kinase.

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Implication

Experimental study demonstrates shared PSGL-1 and CD44 signaling pathways inducing slow leukocyte rolling in mice, highlighting mechanisms governing neutrophil recruitment during inflammation.

Cite This Study

Yago et al. (2010) studied this question.

synapsesocial.com/papers/6a7ad0fcb008f0cadf328249 https://doi.org/10.1182/blood-2009-12-259556

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Implication

Experimental study demonstrates shared PSGL-1 and CD44 signaling pathways inducing slow leukocyte rolling in mice, highlighting mechanisms governing neutrophil recruitment during inflammation.

E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin αLβ2-mediated slow leukocyte rolling

Key Points

Discussion

Implication

Cite This Study

E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin αLβ2-mediated slow leukocyte rolling

Key Points

Discussion

Implication

Cite This Study

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