Why the study?
Does leukocyte-specific β2-adrenergic receptor knockout affect survival and immune cell infiltration after acute myocardial infarction in mice?
Population
Wild-type mice undergoing irradiation followed by bone-marrow transplantation and myocardial infarction…
Comparison
Isoform-specific β2-adrenergic receptor knockout… vs Wild-type (WT) bone-marrow transplantation
Design
Preclinical
Follow-up
12 days
Authors
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Leukocyte β2ARs support post-MI survival in mice; hypothesis-generating for human immune modulation, prospective studies required.
Does leukocyte-specific β2-adrenergic receptor knockout affect survival and immune cell infiltration after acute myocardial infarction in mice?
Leukocyte-expressed β2-adrenergic receptors are essential for survival after acute myocardial infarction by facilitating cardiac leukocyte infiltration and preventing cardiac rupture.
Grisanti et al. (2016) studied this question.
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