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Hepatitis D virus (HDV) is a small satellite virus that is present almost exclusively in persons with chronic hepatitis B virus (HBV) infection because of its dependence on HBV surface antigen (HBsAg) for transmission and infectivity. Among HBsAg-positive persons, approximately 5% are infected with HDV, which corresponds to approximately 12 million persons (95% confidence interval, 8.7 million to 18.7 million) worldwide.1 The estimated prevalence of HDV infection in the United States is low (0.11% of persons).2 Accordingly, chronic HDV infection qualifies for the Food and Drug Administration Orphan Drug Designation Program, a status that is typically granted for diseases that . . .
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Marc G. Ghany (2023) studied this question.
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