Key result
Maternal hyperuricemia is linked to markedly higher perinatal mortality regardless of blood pressure in hypertensive pregnancies.
Observational (n=400)
Answers are grounded in this paper and cite their sources.
The relation of perinatal mortality to plasma-urate concentration and blood pressure was studied in 200 patients with pre-existing hypertension and 200 patients with pre-eclampsia of pregnancy. Perinatal mortality was markedly increased when maternal plasma-urate concentrations were raised, generally in association with severe pre-eclampsia of early onset or superimposed on pre-existing hypertension. Maternal hypertension, even severe, without hyperuricemia was associated with good prognosis for the fetus. When there was hyperuricemia, the prognosis for the fetus was poor irrespective of the level of blood pressure. Pre-eclampsia of pregnancy was associated with high perinatal mortality rate when compared with the rate in pre-existing hypertension. This study suggests that serum urate is a reliable index of fetal welfare when pregnancy is complicated by pre-eclampsia and pre-existing hypertension.
No takes yet. Share an insight, caveat, or question.
T.R. Varma (1982) conducted an observational in Pregnancies complicated by pre-existing hypertension and pre-eclampsia of pregnancy (n=400). Maternal hyperuricemia (raised plasma-urate concentration) vs. Normal maternal plasma-urate concentration (without hyperuricemia) was evaluated on Perinatal mortality. Maternal hyperuricemia markedly increased perinatal mortality irrespective of blood pressure in 400 pregnancies with pre-existing hypertension (n=200) or pre-eclampsia (n=200).
Synapse has enriched 10 related papers. Consider them for comparative context: