Key result
Genomic surveillance of CV-A16 in China from 2000-2018 revealed that cluster B1b dominates its diffusion, and the EV-A71 vaccine introduction in 2016 did not reduce CV-A16 genetic diversity.
Why the study?
To investigate the epidemiological characteristics, spread dynamics, recombinant forms, and other features of coxsackievirus A16, an important cause of hand, foot, and mouth disease.
Population
Surveillance data of CV-A16-related HFMD cases in mainland China
Design
Continuous surveillance genomic epidemiological study
Follow-up
18-year period
Authors
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CV-A16 surveillance may aid regional HFMD preparedness; leaves open questions on recombinant clinical impact.
Observational
Yes
This genomic epidemiological study maps the spread dynamics and genetic diversity of CV-A16 in China over 18 years, highlighting the dominance of the B1b cluster and the need for targeted surveillance.
Han et al. (2020) conducted an observational in Hand, foot, and mouth disease (HFMD). Coxsackievirus A16 (CV-A16) was evaluated on Genetic diversity and spread dynamics of CV-A16. Genomic surveillance of CV-A16 in China from 2000-2018 revealed that cluster B1b dominates its diffusion, and the EV-A71 vaccine introduction in 2016 did not reduce CV-A16 genetic diversity.
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