Highly elevated serum IL-6 in cardiac myxoma may be associated with the rare development of multiple cerebral aneurysms, and IL-6 levels normalize following surgical resection of the tumor.
IL-6 normalization after myxoma resection leaves aneurysm burden unchanged at 6 months; leaves open whether IL-6 contributes to rare aneurysm formation.
Cerebral embolic infarction is the most common neurologic complication of cardiac myxoma (CM). Development of cerebral aneurysms in CM is very rare. We present a 64-year-old woman with acute cerebral infarction and multiple cerebral aneurysms complicated by CM. The aneurysms were multiple, fusiform-shaped, and located in distal branch of major cerebral arteries. The serum interleukin (IL)-6 was highly elevated, which was normalized after surgical resection of CM. There was no regression of aneurysms on follow-up neuroimaging. Multiple cerebral aneurysms in CM are rare condition. Highly elevated serum IL-6 may be associated with increased risk of cerebral aneurysmal formation.
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Koo et al. (2009) studied this question.
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