Highlights the rare but severe delayed complication of multiple fusiform cerebral aneurysms following left cardiac myxoma resection, potentially linked to elevated IL-6.
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May warrant long-term cerebrovascular surveillance after myxoma resection; hypothesis-generating for IL-6 in delayed aneurysm formation.
Left cardiac myxoma and also consecutive embolization into the brain is well documented, whereas the association of myxomas with multiple fusiform cerebral aneurysms is rare. We analyze 33 previously reported patients and present a case of a 43-year-old woman with multiple cerebral infarctions 2 years after resection of a recurrent myxoma in the left atrium. Cerebral angiography displayed multiple fusiform aneurysms of several cerebral arteries, including a giant aneurysm of the basilar artery. Serum level of interleukin-6 (IL-6) was highly elevated. The clinical, radiological and pathological features of these aneurysms are summarized. The pathogenesis, including the role of IL-6 in the formation of myxomatous aneurysms, is discussed.
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Sabolek et al. (2005) studied this question.
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