Why the study?
Are combined antiplatelet agents or antiplatelet agents taken with NSAIDs associated with intraocular haemorrhage?
Are combined antiplatelet agents or antiplatelet agents taken with NSAIDs associated with intraocular haemorrhage?
The combination of antiplatelet agents with NSAIDs may be associated with severe haemorrhagic vitreoretinal complications and copious bleeding during ocular surgery.
May warrant perioperative bleeding caution with combined antiplatelet-NSAID regimens; case reports leave open need for controlled studies.
Antiplatelet agents are increasingly encountered in combination1–3 or taken with non-steroidal anti-inflammatory drugs (NSAIDs), which potentiate their action. We present four cases of intraocular haemorrhage associated with these combinations. An 83 year old man presented with visual acuity reduced to hand motions in both eyes as a result of dense vitreous haemorrhage. He had hypertension, which was being treated, but was not diabetic. Medications included 75 mg clopidogrel once daily and diclofenac. He underwent a right vitrectomy with cryotherapy and gas tamponade. There was copious intraocular and extraocular bleeding that was difficult to control, significantly prolonging surgery. Postoperatively the acuity was still hand motions with persistent vitreous haemorrhage. Clopidogrel and diclofenac were discontinued before left eye surgery. …
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E N Herbert (2006) studied this question.
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