Structure of a new metabolite,dihydroauroglaucin,produced by Aspergillus chevalieri.

Auroglaucin and flavoglaucinhave been known as common metabolites of Aspergillus glaucus group.1]Since we found that auroglaucin showed a mutagenic activity against Salmonella tryphimurium TA 100 as shown in Fig. 1, we surveyed auroglaucin analogues in the metabolites of Aspergillus chevalieri (Mangin) Thorn et Church IFO 4086 and investigated their structure-mutagenic activity relationship.As a result, a new compound designated as dihydroauroglaucin 1 was isolated together with five knownmetabolites which are auroglaucin analogues.In this paper we report the isolation and structural elucidation of 1.