Key result
Cortexin (20 mg/day) with basic therapy and early verticalization provided the most complete regression of neurological deficits and cardiac autonomic neuropathy compared to basic therapy alone.
Why the study?
The study was conducted to evaluate the efficacy and safety of cortexin within rehabilitation measures for verticalization in patients with ischemic stroke during the acute period.
Does cortexin added to basic therapy and early verticalization improve neurological deficits and cardiac autonomic neuropathy in patients with acute ischemic stroke?
Does cortexin added to basic therapy and early verticalization improve neurological deficits and cardiac autonomic neuropathy in patients with acute ischemic stroke?
Cortexin combined with early verticalization and basic therapy may improve neurological and autonomic recovery in the acute period of ischemic stroke.
May aid early verticalization after acute ischemic stroke; hypothesis-generating and requires confirmation in randomized trials.
AIM: To evaluate the efficacy and safety of cortexin in the complex of rehabilitation measures for verticalization in patients with ischemic stroke in the acute period. MATERIAL AND METHODS: The study included 90 patients with hemispheric ischemic stroke. Patients of the first group (n=30) received cortexin in a dose of 20 mg per day intramuscularly for 10 days, along with basic therapy during early verticalization. Patients of the second group (n=30) received basic therapy during early verticalization and patients of the third group (n=30) received only basic therapy without verticalization. To assess the severity of condition, NIHSS, modified Rankin scale, the Barthel index, the Rivermead mobility index, MMSE, MOCA were used. To study cardiovascular function in patients, the segmental part of the autonomic nervous system was studied: a test with isometric load, a Valsalva test, a test based on the change in heart rate with slow deep breathing. All studies were conducted before and 10-14 days after treatment. RESULTS AND CONCLUSION: The most complete regression of neurological deficits and manifestations of cardiac autonomic neuropathy during the acute period of ischemic stroke was observed in the group of patients treated with cortexin (20 mg per day for 10 days), along with basic therapy and early verticalization, compared to the groups, which received basic therapy with early verticalization or basic therapy without verticalization.
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Машин et al. (2019) studied Hemispheric ischemic stroke in the acute period (n=90). Cortexin vs. Basic therapy with early verticalization or basic therapy without verticalization was evaluated on Regression of neurological deficits and manifestations of cardiac autonomic neuropathy. Cortexin (20 mg/day) with basic therapy and early verticalization provided the most complete regression of neurological deficits and cardiac autonomic neuropathy compared to basic therapy alone.
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